Annual report pursuant to Section 13 and 15(d)

Subsequent Events (Details Narrative)

v3.8.0.1
Subsequent Events (Details Narrative) - USD ($)
1 Months Ended 12 Months Ended
Jan. 26, 2018
Jan. 05, 2018
Jan. 01, 2018
Jan. 02, 2017
Feb. 28, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Proceeds from issuance of common stock           $ 78,891,699 $ 16,699,133 $ 11,328,929
Warrant exercisable price per sahre           $ 1.00    
Warrant exercisable shares of common stock           1,288,500 679,500  
Evergreen Provision [Member] | 2014 Equity Incentive Plan [Member]                
Increased number of shares of common stock available for issuance       3,127,722        
Subsequent Event [Member] | Phase 2b Clinical Trial [Member]                
Amount received upon execution of award agreement $ 6,250,000              
Subsequent Event [Member] | Cystic Fibrosis Foundation warrants [Member]                
Warrant to purchase of common stock 1,000,000              
Warrant exercisable price per sahre $ 13.20              
Warrant exercisable shares of common stock 500,000              
Warrant expires date Jan. 26, 2025              
Subsequent Event [Member] | Cystic Fibrosis Program Related Investment Agreement [Member]                
Development award received $ 25,000,000              
Subsequent Event [Member] | Investment Agreement [Member] | Cystic Fibrosis Foundation warrants [Member]                
Warrant exercisable shares of common stock 500,000              
Subsequent Event [Member] | At the Market Offering [Member]                
Number of common stock value sold   $ 50,000,000            
Subsequent Event [Member] | At the Market Offering [Member] | 2018 Sales Agreement [Member]                
Number of common stock share sold         1,500,000      
Proceeds from issuance of common stock         $ 11,349,000      
Subsequent Event [Member] | Evergreen Provision [Member] | 2014 Equity Incentive Plan [Member]                
Increases in number of shares of common stock available for issuance, minimum percentage of outstanding common stock     7.00%          
Increased number of shares of common stock available for issuance     2,500,000          
Percentage of outstanding common shares     7.00%          
Total reserve under the plan     15,543,739          
Shares available for future grants     6,960,334