Annual report pursuant to Section 13 and 15(d)

Cover
- Document and Entity Information
Financial Statements
Notes to Financial Statements
Accounting Policies
- Significant Accounting Policies (Policies)
Notes Tables
Notes Details

Subsequent Events (Details Narrative)

v3.8.0.1

Subsequent Events (Details Narrative) - USD ($)					1 Months Ended	12 Months Ended
Subsequent Events (Details Narrative) - USD ($)	Jan. 26, 2018	Jan. 05, 2018	Jan. 01, 2018	Jan. 02, 2017	Feb. 28, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Proceeds from issuance of common stock						$ 78,891,699	$ 16,699,133	$ 11,328,929
Warrant exercisable price per sahre						$ 1.00
Warrant exercisable shares of common stock						1,288,500	679,500
Evergreen Provision [Member] \| 2014 Equity Incentive Plan [Member]
Increased number of shares of common stock available for issuance				3,127,722
Subsequent Event [Member] \| Phase 2b Clinical Trial [Member]
Amount received upon execution of award agreement	$ 6,250,000
Subsequent Event [Member] \| Cystic Fibrosis Foundation warrants [Member]
Warrant to purchase of common stock	1,000,000
Warrant exercisable price per sahre	$ 13.20
Warrant exercisable shares of common stock	500,000
Warrant expires date	Jan. 26, 2025
Subsequent Event [Member] \| Cystic Fibrosis Program Related Investment Agreement [Member]
Development award received	$ 25,000,000
Subsequent Event [Member] \| Investment Agreement [Member] \| Cystic Fibrosis Foundation warrants [Member]
Warrant exercisable shares of common stock	500,000
Subsequent Event [Member] \| At the Market Offering [Member]
Number of common stock value sold		$ 50,000,000
Subsequent Event [Member] \| At the Market Offering [Member] \| 2018 Sales Agreement [Member]
Number of common stock share sold					1,500,000
Proceeds from issuance of common stock					$ 11,349,000
Subsequent Event [Member] \| Evergreen Provision [Member] \| 2014 Equity Incentive Plan [Member]
Increases in number of shares of common stock available for issuance, minimum percentage of outstanding common stock			7.00%
Increased number of shares of common stock available for issuance			2,500,000
Percentage of outstanding common shares			7.00%
Total reserve under the plan			15,543,739
Shares available for future grants			6,960,334

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