Annual report pursuant to Section 13 and 15(d)

Cover
- Document and Entity Information
Financial Statements
Notes to Financial Statements
Accounting Policies
- Significant Accounting Policies (Policies)
Notes Tables
Notes Details

Income Taxes (Details Narrative)

v3.19.1

Income Taxes (Details Narrative) - USD ($)		12 Months Ended
Income Taxes (Details Narrative) - USD ($)	Dec. 22, 2017	Dec. 31, 2018	Dec. 31, 2017
Income Taxes [Line Items]
Net operating loss carryforwards		$ 82,545,000	$ 56,536,000
Net operating loss carryforwards excess stock-based compensation			1,432,000
Research and development tax credit carryforwards		2,926,000	1,283,000
Deferred tax assets valuation allowance increase		14,583,207	5,088,343
Uncertain tax position
Income tax description		On December 22, 2017, the legislation commonly referred to as the Tax Cut and Jobs Act (the "Tax Act") was enacted into law. The Tax Act, among other things, contains significant changes to corporate taxation, including reduction of the corporate tax rate from a top marginal rate of 35% to a flat rate of 21%; limitation of the tax deduction for interest expense to 30% of adjusted earnings (except for certain small businesses)
Corporate tax rate percentage		21.00%	34.00%
Taxable income percentage		0.00%	0.00%
Federal [Member]
Income Taxes [Line Items]
Operating loss carryforwards expiration year		2029
Massachusett [Member]
Income Taxes [Line Items]
Net operating loss carryforwards		$ 78,152,000	$ 53,110,000
The Tax Cut and Jobs Act of 2017 [Member]
Income Taxes [Line Items]
Taxable income percentage			80.00%
Deferred tax asset			$ 7,815,832
The Tax Cut and Jobs Act of 2017 [Member] \| Orphan Drug Credit [Member] \| Maximum [Member]
Income Taxes [Line Items]
Corporate tax rate percentage		50.00%
The Tax Cut and Jobs Act of 2017 [Member] \| Orphan Drug Credit [Member] \| Minimum [Member]
Income Taxes [Line Items]
Corporate tax rate percentage		25.00%
The Tax Cut and Jobs Act of 2017 [Member] \| Interest Expense [Member]
Income Taxes [Line Items]
Corporate tax rate percentage	30.00%

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