Annual report pursuant to Section 13 and 15(d)

Cover
- Document and Entity Information
Financial Statements
Notes to Financial Statements
Accounting Policies
- Significant Accounting Policies (Policies)
Notes Tables
Notes Details

Common Stock (Details Narrative)

v3.19.1

Common Stock (Details Narrative) - USD ($)				1 Months Ended	3 Months Ended	12 Months Ended
Common Stock (Details Narrative) - USD ($)	Jan. 05, 2018	Oct. 26, 2017	Feb. 28, 2017	Nov. 30, 2017	Mar. 31, 2018	Dec. 31, 2018	Dec. 31, 2017
Common stock, shares authorized						150,000,000	150,000,000
Common stock, par value						$ 0.0001	$ 0.0001
Common stock, shares issued						57,247,496	55,603,427
Common stock, shares outstanding						57,247,496	55,603,427
Gross proceeds from sale of stock						$ 12,052,645	$ 78,891,699
Stock issuance cost						$ 464,680	$ 2,969,837
Issuance of common stock upon exercise of stock options, shares						139,069	272,734
Warrants [Member]
Issuance of common stock upon exercise of warrants, shares						144,069	272,734
Equity Option [Member]
Issuance of common stock upon exercise of stock options, shares						144,069	272,734
Stock Option and Warrants [Member]
Proceeds from exercise of stock options						$ 352,645	$ 189,490
At the Market Offering [Member] \| Maximum [Member]
Number of common stock value sold	$ 50,000,000
Institutional Investors [Member]
Aggregate common stock sold, shares		4,650,000
Purchase price per share		$ 7.00
Gross proceeds from sale of stock		$ 32,550,000		$ 4,589,550
Stock issuance cost		$ 2,184,000
Options to purchase shares of common stock		697,500
Securities Purchase Agreement [Member] \| Institutional and Accredited Investors [Member]
Aggregate common stock sold, shares			3,887,815
Purchase price per share			$ 7.00
Gross proceeds from sale of stock			$ 27,214,705
Stock issuance cost			$ 36,291
January 2018 Sales Agreement [Member] \| Institutional Investor [Member]
Aggregate common stock sold, shares					1,500,000
Gross proceeds from sale of stock					$ 11,200,000
January 2018 Sales Agreement [Member] \| Institutional Investor [Member] \| Remainder of 2018 and Through February 8, 2019 [Member]
Aggregate common stock sold, shares
Gross proceeds from sale of stock
Sales Agreement [Member]
Aggregate common stock sold, shares							1,413,633
Gross proceeds from sale of stock							$ 13,268,208

- Definition

Amount of decrease in additional paid in capital (APIC) resulting from direct costs associated with issuing stock. Includes, but is not limited to, legal and accounting fees and direct costs associated with stock issues under a shelf registration.

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