Annual report pursuant to Section 13 and 15(d)

LIQUIDITY (Details Narrative)

v3.20.4
LIQUIDITY (Details Narrative) - USD ($)
 1 Months Ended 2 Months Ended 12 Months Ended
Jul. 31, 2020
Apr. 07, 2020
Jun. 30, 2020
Mar. 15, 2021
Dec. 31, 2020
Dec. 31, 2019
Aug. 07, 2020
Jul. 28, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Accumulated deficit         $ 304,094,000      
Cash and cash equivalents         85,433,000      
Proceeds from issuance of common stock         142,200,752 $ 40,677,060    
Issuance costs incurred         6,039,423 $ 2,571,552    
Debt face amount         $ 20,000,000      
April 2020 Sale Agreement [Member]                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Shares issued         10,539,374      
Proceeds from issuance of common stock         $ 75,000,000      
Issuance costs incurred         $ 2,250,000      
April 2020 Sale Agreement [Member] | Jefferies LLC [Member] | Maximum [Member]                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Number of common stock shares sold   75,000,000            
Cystic Fibrosis Program Related Investment Agreement [Member] | Phase 2b Clinical trial [Member]                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Consideration payment milestone received $ 5,000,000   $ 5,000,000          
Proceeds from investments on achieving milestones     $ 25,000,000          
Remainder payable upon the achievement of the last remaining milestone $ 2,500,000              
Loan Agreement [Member] | K2 HealthVentures LLC And Ankura Trust Company, LLC [Member]                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Debt face amount               $ 50,000,000
Loan Agreement [Member] | K2 HealthVentures LLC And Ankura Trust Company, LLC [Member] | Tranche One [Member]                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Debt face amount               $ 20,000,000
August 2020 Sale Agreement [Member]                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Shares issued         15,546,151      
Proceeds from issuance of common stock         $ 21,404,000      
Issuance costs incurred         $ 642,000      
August 2020 Sale Agreement [Member] | Subsequent Event [Member]                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Shares issued       25,391,710        
Proceeds from issuance of common stock       $ 58,861,000        
August 2020 Sale Agreement [Member] | Jefferies LLC [Member]                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Commission percentage             3.00%  
Authorized to offer and sell up of common stock             $ 150,000,000