Annual report pursuant to Section 13 and 15(d)

LIQUIDITY (Details Narrative)

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LIQUIDITY (Details Narrative) - USD ($)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Aug. 07, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Retained earnings (accumulated deficit) $ (349,733,764) $ (304,093,338)  
Cash, cash equivalents and investments 97,647,000    
Proceeds from issuance of common stock 62,586,070 142,200,752  
Stock issuance cost $ 1,820,437 $ 6,039,423  
August 2020 Sale Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Shares issued 25,391,710    
Proceeds from issuance of common stock $ 60,681,238    
Stock issuance cost $ 1,820,437    
August 2020 Sale Agreement [Member] | Jefferies LLC [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Commission percentage     3.00%
Authorized to offer and sell up of common stock     $ 150,000,000