Annual report pursuant to Section 13 and 15(d)

INCOME TAXES (Details Narrative)

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INCOME TAXES (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Operating Loss Carryforwards [Line Items]      
Net operating loss carryforwards no expiration $ 186,267,000    
Research and development tax credit carryforwards 8,656,000 $ 9,233,000  
Deferred tax assets valuation allowance increase 1,052,000 23,324,000  
Uncertain tax position 0 0  
Federal [Member]      
Operating Loss Carryforwards [Line Items]      
Net operating loss carryforwards $ 186,267,000 167,399,000  
Operating loss carryforwards expiration year 2029    
Net operating loss carryforwards no expiration $ 103,686,000 103,686,000 $ 103,686,000
Net operating loss carryforwards limitation percentage on taxable income 80.00%    
MASSACHUSETTS [Member]      
Operating Loss Carryforwards [Line Items]      
Net operating loss carryforwards $ 177,171,000 $ 161,143,000  
Foreign Tax Authority [Member] | Other Income [Member]      
Operating Loss Carryforwards [Line Items]      
Proceeds from Income Tax Refunds $ 12,800,000