Annual report pursuant to Section 13 and 15(d)

LIQUIDITY (Details Narrative)

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LIQUIDITY (Details Narrative) - USD ($)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Aug. 07, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Accumulated deficit $ (392,080,667) $ (349,733,764)  
Cash, cash equivalents and marketable debt securities 59,197,000    
Proceeds from Issuance of Common Stock 62,586,070  
Payments of Stock Issuance Costs $ 0 $ 1,820,437  
August 2020 Sale Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Aggregate common stock sold, shares   846,390  
Proceeds from Issuance of Common Stock   $ 60,681,238  
Payments of Stock Issuance Costs   $ 1,820,437  
August 2020 Sale Agreement [Member] | Jefferies LLC [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Commission percentage     3.00%
Authorized to offer and sell up of common stock     $ 150,000,000