Annual report [Section 13 and 15(d), not S-K Item 405]

WARRANTS (Details Narrative)

WARRANTS (Details Narrative) - USD ($)				12 Months Ended
WARRANTS (Details Narrative) - USD ($)	Mar. 06, 2024	Jun. 01, 2023	Jul. 28, 2020	Dec. 31, 2024	Dec. 31, 2023	Oct. 16, 2020	Jan. 26, 2018
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Warrants				36,207	50,207
Issuance of common stock upon exercise of stock options, shares				136,664
Debt face amount				$ 0	$ 16,304,000
Cash Proceeds						$ 0
Warrant [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Issuance of common stock, net of issuance costs, shares				6,087	0
Warrants to purchase shares of common stock, exercised					0
Share-Based Payment Arrangement, Tranche One [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt face amount			$ 20,000,000
CFF Warrant [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Warrants							33,334
Exercise price of warrants							$ 396
Warrant exercisable price per share							$ 396
Investment Agreement [Member] \| CFF Warrant [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Warrants				36,207
Exercise price of warrants				$ 381.14
Warrant exercisable price per share				$ 381.14
Weighted average remaining life of warrants				6 months 3 days
Warrant expire date					Jan. 26, 2025
Loan Agreement [Member] \| K2 HealthVentures LLC [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Exercise price of warrants			$ 208.8
Warrants to purchase shares of common stock, exercised	142,857	194,444	2,873
Warrant exercisable price per share			$ 208.8
Loan Agreement [Member] \| K2 Warrant [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Warrants			2,873
Exercise price of warrants			$ 208.8
Warrants to purchase shares of common stock, exercised			2,873
Warrant exercisable price per share			$ 208.8
Warrant expire date			Jul. 28, 2030
Professional Services Agreement [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Issuance of common stock, net of issuance costs, shares				4,649	0
Professional Services Agreement [Member] \| Warrants [Member] \| Investor Relations Service Provider [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Warrants						14,000
Exercise price of warrants						$ 32.1
Warrant exercisable price per share						$ 32.1
Warrant expire date						Nov. 03, 2025